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The right and left testes of each embryo showed no significant histological differences and were pooled for epigenomic and transcriptomal analyses. Therefore, EE2-induced feminization of ZZ-male gonads is presumed to occur primarily in the gonadal somatic cells. Coser , 4 and Toshi Shioda 2. Although the mechanisms of avian sex determination remains unknown, the genetic sex is experimentally reversible by in ovo exposure to exogenous estrogens ZZ-male feminization or aromatase inhibitors ZW-female masculinization. DNA methylation profiling of chicken embryonic gonads. Criteria for feminization scoring are shown in the table. In chicken embryonic gonads, sexual dimorphism at the level of marker gene expression occurs long before the morphological sexual differentiation initiates on Day 6. Author information Article notes Copyright and License information Disclaimer. Support Center Support Center.

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